Sildenafil-induced cardioprotection in rabbits
نویسندگان
چکیده
منابع مشابه
Sildenafil-induced cardioprotection in rabbits.
In the August issue of this journal, Reffelmann and Kloner [1] reported the effects of sildenafil (Viagra) on myocardial infarct size following ischemia–reperfusion (I– R). These authors showed that pretreatment with 0.7 or 1.45 mg/kg of sildenafil prior to ischemia resulted in no protection against myocardial infarction. These findings are in contrast with a previous study from our laboratory ...
متن کاملProtein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits.
Sildenafil citrate (Viagra) is the most widely used pharmacological drug for treating erectile dysfunction in men. It has potent cardioprotective effects against ischemia-reperfusion injury via nitric oxide and opening of mitochondrial ATP-sensitive K(+) channels. We further investigated the role of protein kinase C (PKC)-dependent signaling pathway in sildenafil-induced cardioprotection. Rabbi...
متن کاملImpact of Mitochondrial Ca2+-Sensitive Potassium (mBKCa) Channels in Sildenafil-Induced Cardioprotection in Rats
BACKGROUND Mitochondrial large-conductance Ca2+-sensitive potassium (mBKCa) channels are involved in myocardial ischemic preconditioning. Their role in sildenafil-induced cardioprotection is unknown. We investigated whether sildenafil-induced acute cardioprotection is mediated by activation of mBKCa channels in the rat heart in vitro. METHODS Male Wistar rats (n = 8 per group) were randomized...
متن کاملSirtuin 1 (SIRT1) Activation Mediates Sildenafil Induced Delayed Cardioprotection against Ischemia-Reperfusion Injury in Mice
BACKGROUND It has been well documented that phosphodiesterase-5 inhibitor, sildenafil (SIL) protects against myocardial ischemia/reperfusion (I-R) injury. SIRT1 is part of the class III Sirtuin family of histone deacetylases that deacetylates proteins involved in cellular stress response including those related to I-R injury. OBJECTIVE/HYPOTHESIS We tested the hypothesis that SIL-induced card...
متن کاملPhospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury
The phosphodiesterase type-5 inhibitor sildenafil has powerful cardioprotective effects against ischemia-reperfusion injury. PKG-mediated signaling has been implicated in this protection, although the mechanism and the downstream targets of this kinase remain to be fully elucidated. In this study we assessed the role of phospholemman (PLM) phosphorylation, which activates the Na(+)/K(+)-ATPase,...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2003
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2003.10.002